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Symptom Frequency (%)
Widespread muscle and joint pain 100%
Fatigue 80%
Sleep difficulties 75%
Numbness and tingling 64%
Dizziness 60%
Swollen feeling in tissues 40%
Aggravating Factors of Pain  
Cold temperature 80%
Anxiety 80%
Poor sleep 76%
Stress 63%
Overuse or trauma 62%
Physical inactivity 48%
Noise 24%
Overlapping Conditions/Symptoms  
Chronic fatigue syndrome 64%
Irritable bowel syndrome 60%
Multiple chemical sensitivity 55%
Headaches 53%
Dizziness 47%
Primary dysmenorrhoeal 45%
Restless legs syndrome 31%
Female urethral syndrome 12%
Dry mouth 12%
Temporomandibular dysfunction Common *
Periodic limb movement Common *
Cognitive impairment Common
   
*These conditions are common in crucial practice, but there is specific data regarding their frequency.  
StudyDrugSubjectsDesignResults
Quintana et al, 1995114MethyiphenidateN = 102 weeksMethylphenidate > PLA
Age = 7 - 11Crossover
Handen et al, 2000115MethylphenidateN = 131 weekMethylphenidate > PLA
Age = 5 - 11Crossover8/13 (62%) responded
RUPP Autism Network, 2005116MethylphenidateN = 721 weekMethylphenidate > PLA
Age = 5 - 14Crossover
Arnold et al, 2006127AtomoxetineN = 166 weeksAtomoxetine > PLA
Age = 5 - 15Crossover
Jaselskis et al, 1992130ClonidineN = 86 weeksClonidine > PLA by teacher and parent,
Age = 5 - 13Crossoverbut not clinician
6/8 (75%) responders at 1-year follow-up
Fankhauser et al, 1992131Clonidine (transdermal)N = 94 weeksClonidine > PLA
Age = 5 - 33Crossover6/9 (67%) responders

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